Friday, January 27, 2012
These Tiny Snails Are So Small They Look Like Cute Little Boogers [Bugs]
SKorea staging artillery drills at border island (AP)
SEOUL, South Korea ? South Korea staged live-fire drills Thursday from a front-line island shelled by North Korea in 2010, the first such exercise since North Korean leader Kim Jong Il died last month.
Marines at Yeonpyeong Island and nearby Baengnyeong Island fired artillery into waters near the disputed sea border during the two-hour-long drills, a South Korean Defense Ministry official said. The drills were routine exercises and there haven't been any suspicious activities by North Korea's military, the official said on condition of anonymity, citing department rules.
South Korea last held artillery drills at the front-line islands on Dec. 12, five days before Kim Jong Il died of a heart attack, the official said. Similar drills at Yeonpyeong in November 2010 triggered a North Korean artillery bombardment that killed four South Koreans.
Ties between the two Koreas remain frosty with North Korea vowing to retaliate against South Korea over its decision to bar all of its citizens, except for two private delegations, from visiting to pay respects after Kim's death.
The two sides are still technically at war because their conflict in the early 1950s ended with an armistice, not a peace treaty.
Tension between the countries sharply rose in 2010 in the wake of North Korea's shelling of Yeonpyeong and a deadly warship sinking blamed on Pyongyang. North Korea has flatly denied its involvement in the sinking that killed 46 sailors.
South Korean and U.S. troops regularly conduct joint military drills, drawing angry responses from North Korea, which consider them as a rehearsal for a northward invasion.
On Sunday, Pyongyang's official Korean Central News Agency blasted South Korea and the United States over reports they plan a large-scale amphibious drills in March. A KCNA dispatch said the planned drills showed the allies' "wild design to stifle (North Korea) by force of arms."
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Thursday, January 26, 2012
Okay, this one is cool. I promise!
Okay so this idea I dreamed up and I thought it was so awesome I'd share it with you guys! The setting is somewhat cyberpunk but has the 'reclaimed tech' feel of panzerdragoon orta to make an example, think about that for a second, watch a few videos. Got the idea? Great!
The basic plot will probably be something around the people of a small island getting brought into the conflict of two bigger countries who are vying for control of the whole world obviously. They're trying to accomplish this with the use of 'mex' living creatures of organic metal who were created by a far superior civilisation before the fabled 'fall of the world' some hundreds of years ago. At the roleplay start you'd ether be from one country, the other, or the neutral island and forced to pick sides eventually, you'd also start off with a mex or get found by one in need of a rider, even if you think you don't have the talent to ride one. Neutral people don' start off with one since they've been out of the loop.
Also to avoid people going all dragon wars on this I'm thinking of limiting the amount of dragons, maybe giving better options. Good idea? All mex are winged regardless after all.
Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/7-a4FYi9jAM/viewtopic.php
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Rebel leader demands new Papua New Guinea gov't
FILE - In this Dec. 14, 2011 file photo, veteran leader Sir Michael Somare, second right, attends a press conference after claiming to have been reinstated as Papua New Guinea's prime minister in Port Moresby, Papua New Guinea. Rebel soldiers seized the military's headquarters Thursday, Jan. 26, 2012 and replaced Papua New Guinea's top defense official with their own leader, who gave Prime Minister Peter O'Neill a week to step aside for his ousted predecessor. The self-proclaimed new leader of the country's defense forces, retired Col. Yaura Sasa, insisted he was not mounting a coup. But he warned that the military will take unspecified action unless O'Neill stands down and former prime minister Somare, is reinstated, as the national Supreme Court ordered last month. (AP Photo/Post-Courier, File) EDITORIAL USE ONLY
FILE - In this Dec. 14, 2011 file photo, veteran leader Sir Michael Somare, second right, attends a press conference after claiming to have been reinstated as Papua New Guinea's prime minister in Port Moresby, Papua New Guinea. Rebel soldiers seized the military's headquarters Thursday, Jan. 26, 2012 and replaced Papua New Guinea's top defense official with their own leader, who gave Prime Minister Peter O'Neill a week to step aside for his ousted predecessor. The self-proclaimed new leader of the country's defense forces, retired Col. Yaura Sasa, insisted he was not mounting a coup. But he warned that the military will take unspecified action unless O'Neill stands down and former prime minister Somare, is reinstated, as the national Supreme Court ordered last month. (AP Photo/Post-Courier, File) EDITORIAL USE ONLY
FILE - In this Dec. 15, 2011 file photo, Peter O'Neill, center, addresses his supporters in Port Moresby, Papua New Guinea, as controversy on who is the legitimate prime minister continues. Rebel soldiers seized the military's headquarters Thursday, Jan. 26, 2012 and replaced Papua New Guinea's top defense official with their own leader, who gave Prime Minister O'Neill a week to step aside for his ousted predecessor. The self-proclaimed new leader of the country's defense forces, retired Col. Yaura Sasa, insisted he was not mounting a coup. But he warned that the military will take unspecified action unless O'Neill stands down and former prime minister Sir Michael Somare, is reinstated, as the national Supreme Court ordered last month. (AP Photo/Post-Courier, File) EDITORIAL USE ONLY
In this April 21, 2010 photo, former Papua New Guinean Prime Minister Michael Somare receives a traditional taiaha at an official welcome ceremony for him in Rotorua, New Zealand. Rebel soldiers seized the military's headquarters Thursday, Jan. 26, 2012 and replaced Papua New Guinea's top defense official with their own leader, who gave Prime Minister Peter O'Neill a week to step aside for his ousted predecessor, Somare. (AP Photo/New Zealand Herald, Ben Fraser) NEW ZEALAND OUT, AUSTRALIA OUT
FILE - In this Sept. 24, 2011 file photo, Prime Minister of Papua New Guinea Peter O'Neill addresses the 66th session of the United Nations General Assembly at U.N. headquarters in New York. Rebel soldiers seized the military's headquarters Thursday, Jan. 26, 2012 and replaced Papua New Guinea's top defense official with their own leader, who gave O'Neill a week to step aside for his ousted predecessor. The self-proclaimed new leader of the country's defense forces, retired Col. Yaura Sasa, insisted he was not mounting a coup. But he warned that the military will take unspecified action unless O'Neill stands down and former prime minister Sir Michael Somare, is reinstated, as the national Supreme Court ordered last month. (AP Photo/Mary Altaffer, File)
PORT MORESBY, Papua New Guinea (AP) ? Rebel soldiers seized the military's headquarters Thursday and replaced Papua New Guinea's top defense official with their own leader, who gave Prime Minister Peter O'Neill a week to step aside for his ousted predecessor.
The self-proclaimed new leader of the country's defense forces, retired Col. Yaura Sasa, insisted he was not mounting a coup. But he warned that the military will take unspecified action unless O'Neill stands down and former prime minister Michael Somare, is reinstated, as the national Supreme Court ordered last month.
"Both Sir Michael Somare and O'Neill have seven days to implement the Supreme Court's orders to resolve the current political impasse or I will be forced to take actions to uphold the integrity of the Constitution," Sasa told reporters in Port Moresby.
The government called on Sasa and his supporters to surrender and said the mutiny did not have support from the broader military.
Deputy Prime Minister Belden Namah told reporters that about 30 soldiers were involved in the mutiny and 15 of them have been arrested. Namah said Sasa could be charged with treason, which carries the death sentence.
The new crisis comes during a turbulent period for the South Pacific's most populous island nation, where both O'Neill and Somare claim to be the rightful prime minister.
Rebel soldiers overpowered guards at the Taurama Barracks in Port Moresby before dawn. They then moved to the military headquarters at Murray Barracks and placed the head of the Papua New Guinea Defense Force, Brigadier General Francis Agwi, under house arrest. There were no reports of bloodshed.
Sasa, who last served as Papua New Guinea's defense attache to Indonesia before retiring from the military, told reporters he had been legitimately appointed defense chief by Somare.
Somare's spokeswoman Betha Somare told Australian Broadcasting Corp. that his ousted cabinet had confirmed Sasa's appointment several days ago. Betha Somare, who is also Michael Somare's daughter, did not immediately reply to The Associated Press' request for comment on Thursday.
Namah said Somare had "no sanity" and was using "rogue soldiers to pursue his own greed and selfishness."
O'Neill had told Australia ? Papua New Guinea's former colonial master and main provider of foreign aid ? that "authorities were taking steps to manage the situation," Australia's Department of Foreign Affairs and Trade said.
Somare was Papua New Guinea's first prime minister when it became independent in 1975, and was knighted by Britain's Queen Elizabeth II. Papua New Guinea's Parliament replaced him with O'Neill in August, while Somare was getting medical treatment outside the country.
Last month, the country's Supreme Court and Governor-General Michael Ogio backed Somare, who the court ruled was illegally removed. But Ogio changed his mind days later, saying bad legal advice had led him to incorrectly reinstate Somare.
Australia, which has the largest diplomatic mission of any country in Port Moresby, called for Agwi to be reinstated.
"We urge that the situation be resolved as soon as possible, and that the PNGDF chain of command is restored," the foreign affairs department said in a statement.
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Wednesday, January 25, 2012
Exclusive peek: B.H. 'Housewives' wedding finale
Bravo
By Anna Chan
A fairy tale scene in the backyard of a mansion. Smoking drinks. Fancy food. Giant invites featuring white flowers and a price tag of $15,000. Fans of "The Real Housewives of Beverly Hills" have seen all this and more as star Lisa Vanderpump planned daughter Pandora's lavish wedding this season.
Did we say "lavish"? We really meant "simple," as Lisa has insisted during multiple meetings with fab wedding planner Kevin Lee. ("It's Beverly Hills, dahling! It has to be over the top!" he often reminded her.)
Now, viewers will finally see just how "simple" Pandy's August nuptials to long-time love, Jason,?were. The happy celebration is set to cap off the second season of Bravo's hit reality show Monday, which has been filled with allegations of domestic violence and possible drug abuse.
And though Lisa may have insisted on not going over the top, fellow co-star Camille Grammer reveals in an exclusive clip of the finale? provided to us by Bravo that "it definitely looked like a million-dollar wedding." Check it out:
According to our pals at Us Weekly, two of the "Housewives" weren't in attendance. One was Taylor Armstrong, whose husband, Russell, committed suicide just weeks before, and the other was Kim Richards. Seeing as how Kim has created quite a bit of drama this season with her regular tardiness and loopy behavior, we doubt the bride missed her presence.
While planning her wedding, Pandy admitted to mom Lisa that she wasn't sure the "Housewives" would behave on her big day. "Every single time your friends get together, it's a battle," she pointed out in an earlier episode.
In addition to what could be a drama-free wedding for the bride and groom, the ceremony might also bring the gift of?a second straight week of?good news for the show. Last Monday's episode, which featured the opening of Lisa's SUR lounge, was the highest-rated episode in the series' history.
"The Real Housewives of Beverly Hills" finale airs at 9 p.m. on Bravo Monday.
Think the "Housewives" will keep the drama to the minimum without Kim and Taylor there? Share your thoughts on our Facebook page!
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Tuesday, January 24, 2012
Romney paid $3M in federal income tax in 2010 (AP)
WASHINGTON ? Republican presidential candidate Mitt Romney paid about $3 million in federal income taxes in 2010, having earned more than seven times that from his investments and making him among the wealthiest of American taxpayers.
At the same time, Romney gave nearly $3 million to charity ? about half of that amount to the Mormon Church ? which helped lower his effective tax rate to a modest 14 percent, according to records his campaign released early Tuesday.
For 2011, he'll pay about $3.2 million with an effective tax rate of about 15.4 percent, the campaign said. Those returns haven't yet been filed yet with the Internal Revenue Service.
The former Massachusetts governor had been under pressure in recent weeks to release his tax returns, his GOP opponents casting him as a wealthy businessman who slashed jobs in the private sector. Rival Newt Gingrich made public his returns on Saturday, showing he paid almost $1 million in income taxes ? a tax rate of about 31 percent.
Romney's campaign confirmed the details of his tax information after several news organizations saw a preview of the documents. He had said planned to release his returns in full Tuesday morning, and campaign officials would be prepared to discuss them in detail with reporters.
"You'll see my income, how much taxes I've paid, how much I've paid to charity," Romney said during Monday night's debate in Tampa. "I pay all the taxes that are legally required and not a dollar more. I don't think you want someone as the candidate for president who pays more taxes than he owes."
Romney's 2010 returns show the candidate is among the top 1 percent of taxpayers. The returns showed about $4.5 million in itemized deductions, including $1.5 million to the Church of Jesus Christ of Latter-Day Saints.
Before the tax records were released, Romney's old investments in two controversial government-backed housing lenders stirred up new questions at the same time his campaign targeted Gingrich for his work for Freddie Mac.
Gingrich earned $1.6 million in consulting fees from Freddie Mac even though Romney has as much as $500,000 invested in the U.S.-backed lender and its sister entity, Fannie Mae.
The dimensions and the sources of Romney's wealth, which he has estimated to be as much as $250 million, have become pivotal issues in the roiling GOP primary campaign. For months, Romney dismissed calls to release his personal income tax records. But after mounting criticism from his rivals and others, coupled with his stinging weekend loss to Gingrich in the South Carolina primary, Romney agreed to release his 2010 return and 2011 estimate.
Romney already has acknowledged that his current tax rate is about 15 percent, a level far lower than standard rates for high-income earners and similar to the capital gains rate. "I'm proud of the fact that I pay a lot of taxes," Romney said.
The current lowest rate for long-term capital gains is 15 percent, but a higher rate of 20 percent had been in effect since 1981 until President George W. Bush signed into law a massive tax cut program in 2001.
Romney's vast investments contain other funds than the ones he profited from as a Bain Capital executive. But it was unclear whether he had any direct role in handling the investments in Fannie Mae and Freddie Mac that appear on his 2012 presidential disclosure.
One investment, listed as a "Federated Government Obligation Fund" and worth between $250,000 and $500,000, was a mutual fund that included both Fannie Mae and Freddie Mac assets among a larger pool that included other government securities.
The holding was not listed in Romney's blind trust, which led some Democratic Party activists to suggest that the investment was under his direct control.
"He is relentlessly attacking Newt Gingrich over his ties to Freddie Mac despite the fact that he personally invested up to a half a million dollars in both Fannie Mae and Freddie Mac," said Ty Matsdorf, a senior adviser with American Bridge 21st Century, a PAC associated with Democratic Party and liberal causes.
Former GOP Rep. J.C. Watts, a Gingrich supporter, said Monday that Romney was on a slippery slope calling his opponent a lobbyist and raising doubts about Gingrich's work for Freddie Mac. But he did not directly address Romney's investments with the lender or with Fannie Mae.
"Some might see it as splitting hairs. But Newt Gingrich was not walking the halls of House and Senate," Watts said on a conference call arranged by the campaign. "He was never doing the hand-to-hand combat doing the lobbying, consulting, whatever you want to call it."
A Romney campaign official who insisted on anonymity to discuss that investment in greater detail said that Romney's trustee had bought the government investment fund in 2007, before the housing crisis broke.
The Romney official said that the government fund was purchased through a charity trust that does not appear in Romney's presidential disclosure but will show up on his income tax return for 2010. That trust, called a Charitable Remainder Unitrust, is a standard tax strategy among the wealthy that provides investors with a fixed payout each year. What remains in the account at a later date, or when the investor dies, is turned over to charity, the official said.
Romney does not directly control the investment account, Romney campaign senior adviser Eric Fehrnstrom said earlier on Monday. "His investments are controlled by a trustee," Fehrnstrom said.
Separately, Romney's IRA retirement account lists both a Fannie Mae and a Freddie Mac security, each worth between $100,000 and $250,000. But because those are in Romney's IRA, they also appear to be under control of the trustee.
Tax experts said Romney's income tax returns may contain other charity structures and tax strategies designed to both boost his income and charity donations, while minimizing his involvement because of his presidential ambitions.
___
Associated Press writers Kasie Hunt and Brian Bakst in Tampa contributed to this report.
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Wall Street rests after rally; bellwether earnings ahead (Reuters)
NEW YORK (Reuters) ? Stocks finished almost flat on Monday as investors took a break from a recent rally, awaiting earnings from bellwethers such as Apple later in the week.
The S&P 500 is up nearly 5 percent so far this year as an improving U.S. economy has bolstered investor optimism. The Dow and the S&P 500 both had their best weekly performances in a month last week.
"Investors are reserved after a mixed bag of results. Many companies have announced sluggish results, portraying a cautious environment going forward," said Robert Lutts, chief investment officer at Cabot Money Management in Salem, Massachusetts.
"The expectations are very moderate in the market, so a little bit of good news could lead to a significant pop in a stock."
According to Thomson Reuters data, 15 percent of S&P 500 companies have reported earnings, and just 59 percent posted results above Wall Street's expectations. That percentage trails the average of about 70 percent, though the rate is expected to improve as the earnings season gathers steam.
Among the 117 S&P 500 companies expected to report earnings this week is tech company Apple Inc (AAPL.O), due after the closing bell on Tuesday.
The euro-zone crisis remained in the background for the market but has had less of an effect on stocks lately. Germany and France pushed for a deal between Greece and its private creditors, and the two said they still were dedicated to a new bailout that Athens needs by March to stave off default.
The Dow Jones industrial average (.DJI) slipped 11.66 points, or 0.09 percent, to end at 12,708.82. But the Standard & Poor's 500 Index (.SPX) inched up 0.62 point, or 0.05 percent, to close at 1,316.00. And the Nasdaq Composite Index (.IXIC) dipped 2.53 points, or 0.09 percent, to end at 2,784.17.
TEXAS INSTRUMENTS UP LATE
After the bell, Texas Instruments Inc (TXN.O) shares rose 2.5 percent to $34.00 after reporting higher-than-expected fourth-quarter revenue.
In addition to Apple, a number of Dow components are due to report earnings on Tuesday, notably Verizon Communications Inc (VZ.N), Travelers Companies Inc (TRV.N), McDonald's Corp (MCD.N), DuPont (DD.N) and Johnson & Johnson (JNJ.N).
Wall Street's agenda includes the Federal Reserve's first policymaking meeting of the year, which will begin on Tuesday and conclude on Wednesday with a statement. The Fed is likely to say that it will not start raising interest rates again until the first half of 2014, more than five years after cutting them to near zero, a Reuters poll of leading Wall Street economists showed.
The U.S. central bank will begin a new practice of announcing policymakers' interest-rate projections when this week's meeting ends on Wednesday.
During Monday's regular session, Halliburton Co (HAL.N) shares fell 2.1 percent to $35.44 after the world's second-largest oilfield services group warned that the deep slump in U.S. natural gas prices could cause near-term disruptions that pinch first-quarter earnings.
On a positive note, Chesapeake Energy Corp (CHK.N) gained 6.3 percent to $22.28 after it said it will reduce dry gas drilling and cut production in response to natural gas prices falling below "economically attractive" levels. Natural gas companies' shares were among the day's best performers, with an index of those stocks (.XNG) rising 3.6 percent.
Research In Motion Ltd (RIM.TO)(RIMM.O) fell 8.5 percent to $15.56 as analysts were skeptical about the resignation of the BlackBerry maker's co-chief executives.
Sears Holding Corp (SHLD.O) fell 3.3 percent to $47.39 after rising as high as $54.76 in what analysts said could be a short squeeze.
The stock is the most shorted stock in the S&P 500, according to Data Explorers, with 94 percent of shares available used to sell short. The retailer has been the best-performing stock in the index for the year, up more than 50 percent.
"That is a classic short squeeze. There have been headlines all over the name now for the better part of a month or so, and it's largely been quite negative," said Peter Kenny, managing director at Knight Capital in Jersey City, New Jersey.
Trading volume was at about 6.6 billion shares on the New York Stock Exchange, NYSE Amex and Nasdaq, in line with the daily average of 6.68 billion.
Advancers outnumbered decliners on the NYSE by a ratio of about 3 to 2. In contrast, on the Nasdaq, about six stocks fell for every five that rose.
(Reporting By Angela Moon; Editing by Kenneth Barry and; Jan Paschal)
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Monday, January 23, 2012
ASUS sneak attacks the business world with 12.5-inch B23E laptop ...
ASUS was plenty busy at CES last week, but it held back at least one product on us -- the B23E. This 12.5-inch business laptop packs a Core i5 or i7, up to 8GB of RAM and a maximum 750GB hard drive in a magnesium-aluminum alloy case. Other expected Pro-series niceties are also in tow, including a fingerprint reader, spill-proof keyboard and an anti-shock mounted hard disk. Looking at the spec sheet though, it's not all gravy for this 3.4-pound PC. For one ASUS doesn't state how long it will last on a charge, but we can't imagine the three-cell 4,400mAh battery is going to impress with its longevity. We're also sad to see resolution top out at a pedestrian 1366 x 768. For more details hit up the product page at the source link.
Source: http://www.engadget.com/2012/01/22/asus-sneak-attacks-the-business-world-with-12-5-inch-b23e-laptop/
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Giants' tight end Ballard questionable with knee swelling (Reuters)
EAST RUTHERFORD, New Jersey (Reuters) ? New York Giants tight end Jake Ballard missed practice for Sunday's NFC title game because of swelling in his knee, and several other Giants were limited in training but listed as probable for the showdown in San Francisco against the 49ers.
Ballard was listed as questionable for the clash that will produce the NFC representative in the Super Bowl, while center David Baas (illness), wide receiver Hakeem Nicks (ankle) and running back Ahmad Bradshaw (foot) were considered probable for the game.
"They did a little procedure yesterday and he's got a little swelling," Giants coach Tom Coughlin told reporters about Ballard, declining to divulge anything more other than to say it did not involve surgery.
"He's very important, as they all are. He's had an outstanding year," Coughlin said. "He gives us a big strong body blocking and also has done a very good job of getting open and catching the ball."
Nicks, who caught four touchdown passes in New York's playoff wins over the Atlanta Falcons and Green Bay Packers, turned his ankle during Thursday's practice but it was not considered a serious problem.
"He's got a little basketball ankle that from time to time he rolls, and he did it to a certain extent this afternoon," the coach said. "He doesn't think it's going to be too bad."
Baas missed practice because of a stomach bug. Quarterback Eli Manning quit during practice Wednesday because of a similar complaint, but returned to his regular work routine Thursday.
Coughlin was asked if the team was taking any precautions to keep the sick bug from racing through the team.
"Everybody's wearing masks, everybody's washing their hands, everybody's doing everything they can. Like when your sister came home with whatever and you got it. So there's where we are," joked Coughlin.
Offensive lineman Kevin Boothe was unconcerned about his line-mate.
"The good thing is Eli bounced back quickly. Dave is already starting to feel better so he'll be fine," Boothe said.
Bradshaw's foot problem has been a lingering issue for the Giants, who have routinely limited him in practice to ensure he is ready to go by game time.
The possible loss of Ballard was of greater concern and could have an impact on the Giants' attack, both on the ground and in the air.
"They are vital," Boothe said about the tight ends. "In the run game they're an extra lineman and in the pass game they're an extra receiver. Often the big runs result from their blocks that seal the edge or cut off a man off the edge."
Travis Beckham, who along with Bear Pascoe serve as back-ups to Ballard, said the tight end could be a factor in Sunday's game and that he was ready if needed.
"I think I did a good job when he was out earlier," Beckham said. "I'm sure he'll be back tomorrow, but I'm ready to step in."
"I think there's some holes, some gaps in the defense we saw from the last time we played them" that could be exploited by a pass-receiving tight end, he said.
(Editing by Julian Linden)
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Sunday, January 22, 2012
Wayne State University research to shed light on bone metastasis in prostate cancer
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 20-Jan-2012[ | E-mail |
Share ] Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
DETROIT -- Prostate cancer is the most frequent and second deadliest cancer men face. A team of Wayne State University researchers recently received $363,660 from the National Cancer Institute of the National Institutes of Health for the project "Bone-induced c-kit in prostate cancer cells: implications for bone metastasis" that aims to shed new light on implications for bone metastasis in prostate cancer.
As cancer grows in the prostate, cancerous cells can enter the bloodstream and spread to other parts of the body, particularly into the bones. These metastases are the primary cause of death in prostate cancer patients. Current treatments available for prostate cancer with bone metastases can only slow the growth of cancer cells or relieve symptoms.
According to R. Daniel Bonfil, Ph.D., associate professor of urology and pathology in WSU's School of Medicine and principal investigator of the project, the mechanisms by which prostate cancer cells take root and start growing once they become lodged in the bones are not well understood. In addition, Bonfil stated that cells respond to specific signals, or ligands, coming from the tissue where they are located through receptors usually expressed on their surface. When these receptors are activated by their specific ligands, changes in cell behavior occur.
"Our research aims to investigate the contribution of a receptor known as c-kit in the metastasis of prostate cancer to the bone," said Bonfil. "Through our previous research, we have reported for the first time that the expression of the c-kit receptor is augmented in bone metastasis of prostate cancer patients. We also observed that while c-kit is not produced in prostate cancer cells grown alone outside the body, the expression of the receptor is specifically turned on in the same cells when they contact bone cells either in vitro or in vivo, which implies a role for c-kit and its ligand in prostate cancer bone metastasis."
Bonfil and Hyeong-Reh Choi Kim, Ph.D., professor of pathology in WSU's School of Medicine, hypothesize that factors derived from the bone stimulate the production of c-kit and its ligand in prostate cancer cells, facilitating the growth and survival of metastatic cells to the bone, causing them to be less susceptible to chemotherapy.
Through genetic engineering, the team will modify the prostate cancer cells so they fail to produce c-kit. They will compare the growth of these cells within bone to control prostate cancer in which c-kit induction occurs, with the goal of determining the contribution of c-kit to bone metastasis. In addition, they will study the role of c-kit resistance to chemotherapeutic treatment.
"We anticipate that our research will shed light on a novel biological mechanism involved in bone metastasis, providing the foundation for the development of new tailored treatments that will eliminate morbidity and mortality due to this common complication in prostate cancer patients," said Bonfil.
###
Wayne State University is one of the nation's pre-eminent public research institutions in an urban setting. Through its multidisciplinary approach to research and education, and its ongoing collaboration with government, industry and other institutions, the university seeks to enhance economic growth and improve the quality of life in the city of Detroit, state of Michigan and throughout the world. For more information about research at Wayne State University, visit http://www.research.wayne.edu.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 20-Jan-2012[ | E-mail |
Share ] Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
DETROIT -- Prostate cancer is the most frequent and second deadliest cancer men face. A team of Wayne State University researchers recently received $363,660 from the National Cancer Institute of the National Institutes of Health for the project "Bone-induced c-kit in prostate cancer cells: implications for bone metastasis" that aims to shed new light on implications for bone metastasis in prostate cancer.
As cancer grows in the prostate, cancerous cells can enter the bloodstream and spread to other parts of the body, particularly into the bones. These metastases are the primary cause of death in prostate cancer patients. Current treatments available for prostate cancer with bone metastases can only slow the growth of cancer cells or relieve symptoms.
According to R. Daniel Bonfil, Ph.D., associate professor of urology and pathology in WSU's School of Medicine and principal investigator of the project, the mechanisms by which prostate cancer cells take root and start growing once they become lodged in the bones are not well understood. In addition, Bonfil stated that cells respond to specific signals, or ligands, coming from the tissue where they are located through receptors usually expressed on their surface. When these receptors are activated by their specific ligands, changes in cell behavior occur.
"Our research aims to investigate the contribution of a receptor known as c-kit in the metastasis of prostate cancer to the bone," said Bonfil. "Through our previous research, we have reported for the first time that the expression of the c-kit receptor is augmented in bone metastasis of prostate cancer patients. We also observed that while c-kit is not produced in prostate cancer cells grown alone outside the body, the expression of the receptor is specifically turned on in the same cells when they contact bone cells either in vitro or in vivo, which implies a role for c-kit and its ligand in prostate cancer bone metastasis."
Bonfil and Hyeong-Reh Choi Kim, Ph.D., professor of pathology in WSU's School of Medicine, hypothesize that factors derived from the bone stimulate the production of c-kit and its ligand in prostate cancer cells, facilitating the growth and survival of metastatic cells to the bone, causing them to be less susceptible to chemotherapy.
Through genetic engineering, the team will modify the prostate cancer cells so they fail to produce c-kit. They will compare the growth of these cells within bone to control prostate cancer in which c-kit induction occurs, with the goal of determining the contribution of c-kit to bone metastasis. In addition, they will study the role of c-kit resistance to chemotherapeutic treatment.
"We anticipate that our research will shed light on a novel biological mechanism involved in bone metastasis, providing the foundation for the development of new tailored treatments that will eliminate morbidity and mortality due to this common complication in prostate cancer patients," said Bonfil.
###
Wayne State University is one of the nation's pre-eminent public research institutions in an urban setting. Through its multidisciplinary approach to research and education, and its ongoing collaboration with government, industry and other institutions, the university seeks to enhance economic growth and improve the quality of life in the city of Detroit, state of Michigan and throughout the world. For more information about research at Wayne State University, visit http://www.research.wayne.edu.
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Sensixa e-AR duplicates the inner ear, knows if you've fallen and can't get up
Sensixa e-AR duplicates the inner ear, knows if you've fallen and can't get up originally appeared on Engadget on Sun, 22 Jan 2012 01:52:00 EDT. Please see our terms for use of feeds.
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Saturday, January 21, 2012
Join us for a podcast liveblog!
Join us for a podcast liveblog! originally appeared on Engadget on Thu, 19 Jan 2012 17:07:00 EDT. Please see our terms for use of feeds.
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Why did boarding school grad join al-Qaida?
Moeed Abdul Salam didn't descend into radical Islam for lack of other options. He grew up in a well-off Texas household, attended a pricey boarding school and graduated from one of the state's most respected universities.
But the most unlikely thing about his recruitment was his family: Two generations had spent years promoting interfaith harmony and combating Muslim stereotypes in their hometown and even on national television.
Salam rejected his relatives' moderate faith and comfortable life, choosing instead a path that led him to work for al-Qaida. His odyssey ended late last year in a middle-of-the-night explosion in Pakistan. The 37-year-old father of four was dead after paramilitary troops stormed his apartment.
His Nov. 19 death went largely unnoticed in the U.S. and rated only limited attention in Pakistan. But the circumstances threatened to overshadow the work of an American family devoted to religious understanding.
Mom: 'Have to let go'
And his mysterious evolution presented a reminder of the attraction Pakistan still holds for Islamic militants, especially well-educated Westerners whose Internet and language skills make them useful converts for jihad.
"There are things that we don't want to happen but we have to accept, things that we don't want to know but we have to learn, and a loved one we can't live without but have to let go," Salam's mother, Hasna Shaheen Salam, wrote last month on her Facebook page.
The violence didn't stop after Salam died. Weeks after his death, fellow militants killed three soldiers with a roadside bomb to avenge the raid.
It is not clear to what extent Salam's family knew of his radicalism, but on his Facebook page the month before he died, he posted an image of Anwar al-Awlaki, the American al-Qaida leader who was killed in a U.S. drone strike in Yemen, beside a burning American flag.
He had also recently linked to a document praising al-Awlaki martyrdom and to a message urging Muslims to rejoice "in this time when you see the mujahideen all over the world victorious."
After his death, the Global Islamic Media Forum, a propaganda group for al-Qaida and its allies, hailed Salam as a martyr, explaining in an online posting that he had overseen a unit that produced propaganda in Urdu and other South Asian languages.
A senior U.S. counterterrorism official said Salam's role had expanded over the years beyond propaganda to being an operative. The official spoke on condition of anonymity because of the sensitivity of the information.
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The family, originally from Pakistan, immigrated to the U.S. decades ago. Salam's father was a pilot for a Saudi airline, and the family eventually settled in the Dallas suburb of Plano. Their cream-colored brick home, assessed at nearly $400,000, stands on a corner lot in a quiet, upper-class neighborhood.
Studied history
The family obtained American citizenship in 1986. Salam attended Suffield Academy in Connecticut, a private high school where tuition and board currently run $46,500. He graduated in 1992.
A classmate, Wadiya Wynn, of Laurel, Md., recalled that Salam played varsity golf, sang in an a cappella group and in the chamber choir, and that he hung out with a small group of "hippie-ish" friends.
She thought he was a mediocre student, but noted that just being admitted to Suffield was highly competitive.
Salam went on to study history at the University of Texas at Austin and graduated in 1996. His Facebook profile indicated he moved to Saudi Arabia by 2003 and began working as a translator, writer and editor for websites about Islam.
"Anyone can pick up a gun, but there aren't as many people who can code html and understand the use of proxies," said Evan Kohlmann, a senior partner a Flashpoint Global Partners, which tracks radical Muslim propaganda.
Salam, who had apparently been active in militant circles for as long as nine years, arrived three years ago in Karachi, Pakistan's largest city, and became an important link between al-Qaida, the Taliban and other extremists groups, according to an al-Qaida operative in Karachi who spoke on condition of anonymity because he is wanted by authorities.
'Open-minded'
Salam traveled to the tribal areas close to the Afghan border three or four times for meetings with senior al-Qaida and Taliban leaders, the operative said. He would handle money and logistics in the city and deliver instructions from other members of the network.
Back in the United States, Salam's mother is a prominent resident of Plano, where she is co-chairwoman of a city advisory group called the Plano Multicultural Outreach Roundtable, as well as a former president of the Texas Muslim Women's Foundation.
The founder of the latter group, Hind Jarrah, said Shaheen and her husband are too upset to speak with anyone.
"She's a committed American citizen. She's a hard worker," Jarrah said, calling her "one of the nicest, most committed, most open-minded" women she had ever met.
Salam's brother, Monem Salam, has traveled the country speaking about Islam, seeking to correct misconceptions following the 9/11 attacks. He works for Saturna Capital, where he manages funds that invest according to Islamic principles ? for example, in companies that do not profit from alcohol or pork. He recently moved from the company's Bellingham, Wash., headquarters to head its office in Kuala Lumpur, Malaysia.
After the 2001 attacks, he and his wife made a public-television documentary about his efforts as a Muslim man to obtain a pilot's license. They also wrote a column for The Bellingham Herald newspaper that answered readers' questions about Islam.
Both Salam's parents and his brother declined numerous interview requests from The Associated Press.
Since the 2001 terrorist attacks, dozens of U.S. citizens have been accused of participating in terrorism activities, including several prominent al-Qaida propagandists, such as al-Awlaki and Samir Khan, who was killed alongside him. Perhaps best known is Adam Gadahn, an al-Qaida spokesman believed to be in Pakistan.
'Children crying'
Of 46 cases of "homegrown terrorism" in the U.S. since 2001, 16 have a connection to Pakistan, according to a recent RAND Corporation study. Salam's background as college-educated and from a prosperous family isn't unusual among them.
Salam divorced his wife in October, but was contesting custody of their three sons and one daughter. The children were staying with him in the third-floor apartment when a squad of paramilitary troops known as Rangers arrived around 3:30 a.m.
Officers said they pushed through the flimsy door, and Salam killed himself with a grenade when he realized he was surrounded.
The Islamic media group and the al-Qaida contact in Karachi disputed that account, saying Salam was killed by the troops.
Through the windows, blood splatter and shrapnel marks were visible on the wall close to the dining table. There were boxes of unpacked luggage, a treadmill and two large stereo speakers. Residents said Moeed had only been living there for five days.
Neighbor Syed Mohammad Farooq was woken by an explosion. Minutes later, one of the troops asked him to go inside the apartment and see what had happened, he said.
"He was lying on the floor with blood pooling around him. One of his arms had been blown off. I couldn't look for long. He was moaning and seemed to be reciting verses from the Koran," he said. "I could hear the children crying, but I couldn't see them."
Hours later, Salam's wife and father-in-law, a lawyer in the city, came to collect the children from the apartment in Gulistane Jauhar, a middle-class area of Karachi, Farooq said. On the night he died, Salam led evening prayers at the small mosque on the ground floor of the apartment building.
"His Koranic recitation was very good," said Karim Baloch, who prayed behind him that night. "It was like that of an Arab."
Johnson reported from Bellingham, Wash., Brummitt reported from Islamabad, Pakistan. AP news researcher Jennifer Farrar contributed to this report, along with reporters Ashraf Khan in Karachi, Pakistan; Zarar Khan in Islamabad; Adam Goldman in Washington; Danny Robbins and Linda Stewart Ball in Plano, Texas; and Paul Weber and Will Weissert in Austin, Texas.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Source: http://www.msnbc.msn.com/id/46037238/ns/us_news-life/
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Friday, January 20, 2012
Serial killer discovered with DNA evidence (Reuters)
(Reuters) - By Jonathan Allen
NEW YORK, Jan 17 (Reuters) ? A serial killer nabbed after giving a DNA sample in connection with a drunk-driving conviction more than a decade after his murder spree was sentenced to 75 years to life in prison on Tuesday.
Francisco Acevedo, 43, whose case prompted calls for expansion of the state's DNA database to track criminals, was not even a suspect in the murders of three women in Yonkers, New York until he applied for parole in 2009 while in prison for drunk driving, prosecutors said.
He provided a DNA sample as part of his parole application that was, as a matter of routine, entered into the federal Codis database which helps match suspects to DNA evidence taken from crime scenes.
Acevedo never got parole and instead his DNA was linked to the murders of Maria Ramos in 1989, Tawanda Hodges in 1991 and Kimberly Moore in 1996, prosecutors said.
He had sex with each of the women before beating and strangling them, said prosecutors with the Westchester County, New York District Attorney's office.
"This defendant, a serial killer, was incarcerated on another charge and would never have been identified as the killer of these three women had he not voluntarily given a DNA sample so that he could be paroled," said Westchester District Attorney Janet DiFiore in a statement.
DiFiore said the case underlined a need for the expansion of New York State's criminal DNA database, as called for last week by Governor Andrew Cuomo in his State of the State address.
New York currently collects DNA from those convicted of felonies or certain misdemeanors, including petty larceny and violent crimes, but not low-level misdemeanors.
Cuomo, with support from many law-enforcement agencies, said he wants to change the law to expand collection of DNA to include anyone convicted of any crime.
The governor said the state's database, created in 1996, has provided leads in over 2,700 convictions and led to 27 exonerations, but only allows the state to collect DNA from about half of all defendants convicted of crimes.
The state's Division of Criminal Justice Services said it contains more than 410,000 convicted offender profiles.
Officials could not say how often a DNA database match leads to a breakthrough in a so-called cold case, although the Manhattan District Attorney's office has said at least five rape and murder investigations, one dating back to the 1970s, were resolved in 2011 after DNA evidence led to a suspect.
In some instances, prosecutors are able to indict an unknown suspect based on a DNA profile and thereby stop the clock running on the statue of limitations, even in cases where it may take many more years to identify a suspect.
(Editing by Ellen Wulfhorst and Greg McCune)
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Thursday, January 19, 2012
Apple co-founder prefers Android phones, blasts Siri (Appolicious)
Steve Wozniak may have helped Steve Jobs build one of the greatest consumer electronics empires in the world, but this Apple co-founder admits that he loves his Android handset. During an interview with the Daily Beast, the Woz blasts the iPhone for its limitations and highlights a number of perks that Android brings, including voice commands that are better than Siri and navigation. ?My primary phone is the iPhone, I love the beauty of it,? Wozniak says. ?But I wish it did all the things my Android does, I really do.?
The statement was heard around the world, as Wozniak adds fuel to the bitter battle between Apple and Android. It?s a rivalry that hearkens back to the days of Apple versus Microsoft back in the 1990s, where Apple lost out to volume, pricing and accessibility. Wozniak thinks Apple?s mobile strategy may not be differentiated enough, however, saying ?there?s not as big a difference [between iOS and Android] as there was between Mac and Windows.?
Android losing control of its market?
Wozniak goes on to note Apple?s strict app approval process as a sticking point that ultimately gives Android the lead, and this has been a point of contention from day one. Apple?s been slow to give up control over its ecosystem, while Android may have given up too much control with its open app store. Some argue that Android?s openness is contributing to its detriment around fragmentation, some even saying that Google has no chance of regaining control. But it may not be total control Google?s after when it comes to Android. Its open source platform acts as a partner for manufacturers like Samsung and HTC, emboldening the Android ecosystem for rapid expansion and broad consumer appeal. It?s worked out quite well for handset makers, even enabling Samsung to compete on a more direct level with the Apple iPhone.
The dangers of Android patent infringement
But making Android phones does have its downside. Microsoft, the company that first beat out the Macintosh PC some decades ago, is looking to dominate the mobile scene any way it can. This strategy revolves around targeting Android manufacturers for licensing agreements, and Pantech could be next. South Korea?s third largest handset maker is reportedly in talks with Microsoft regarding the patent usage in its Android smartphones, and could end up paying around $5 per Android device sold. HTC and Samsung already have deals with Microsoft, which now collects fees from nearly 70 percent of Android device makers. South Korea?s second-largest handset maker, LG, just signed a deal last week.
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Wednesday, January 18, 2012
XL Group appoints new CEO of Mexico insurance operations
IBR Staff Writer Published 18 January 2012
XL Group, a global insurance and reinsurance company, has appointed Alvaro Salamanca as the new CEO of its operation in Mexico, effective immediately to seek further profitable growth in the Latin American region.
Based in Mexico, Salamanca will report to Bruno Laval, regional manager for Iberia and Latin America at XL's insurance segments.
Prior to XL, Salamanca served as the CEO of a Mexican management consultancy and provided advice to local as well as multinational insurance groups on expansion in Latin America. He also led Chubb's Colombian and Mexican subsidiaries for more than 11 years.
Bruno Laval added that Alvaro had experience in underwriting that will allow him to be a partner for the firm's clients and brokers in Mexico.
XL Insurance segment offers property, casualty, professional and specialty insurance products to industrial, commercial and professional firms, insurance companies and other enterprises worldwide.
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Tuesday, January 17, 2012
RIM to release two more PlayBook tablets in 2012, BlackBerry 10 to follow in September? (Digital Trends)
A roadmap of Research in Motion?s plans for new hardware during 2012 has been leaked. Surprisingly, rather than concentrating on BlackBerry 10 handsets, it features not one but two new BlackBerry PlayBook tablets.
Yes, it seems one tablet not selling very well isn?t enough, as information given to N4bb.com shows a new 7-inch BlackBerry PlayBook will be coming in April, with a 10-inch model to follow at the end of the year in December.
Details on the features are thin, with the leak indicating the new 7-inch PlayBook would have ?3G+?, which most know better as HSDPA/HSUPA or a 3.5G network connection, while the 10-inch tablet will finally get an LTE radio.
As it stands now, the PlayBook tablet only has Wi-Fi, so the addition of a 3G/LTE radio is very welcome, however one has to question whether it?ll be enough to boost sales of the device. Certainly if the 1024 x 600 screen resolution were to be bumped at the same time, it would garner more than just passing interest.
At the moment, PlayBook owners are waiting patiently for the new version of the operating system, demonstrated at CES last week, which N4bb.com?s leak agrees will be coming in February. It also predicts the release of two 2G Curves for emerging markets.
Finally, and perhaps most worryingly, the first BlackBerry 10 smartphone won?t be coming until September, a date which fits in with prior reports of a delay. Plus, like previous rumors have indicated, it does appear RIM will only be launching the new OS on the one phone.
More details on BB 10 are expected at Mobile World Congress next month, but if the release date really is as late as September, it?s unlikely we?ll get to see any hardware at the show.
This article was originally posted on Digital Trends
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France can overcome crisis with reforms: Sarkozy (Reuters)
AMBOISE, France (Reuters) ? President Nicolas Sarkozy said on Sunday France could overcome its debt crisis as long as it was prepared to pull together to adopt economic reforms, two days after the country lost its prized triple-A credit rating.
Sarkozy said he would announce reforms at the end of the month and that he intends to implement them rapidly following talks with union leaders and employers this coming week.
"I will tell them (the French people) the important decisions that we need to take without losing any time," he said in a speech to mark the 100th anniversary of the birth of Michel Debre, father of the constitution of France's Fifth Republic.
"The crisis can be overcome provided we have the collective will and the strength to reform our country."
Three months away from a presidential election, Sarkozy has turned his focus to growth, vowing to overhaul welfare financing, company labor charges and job flexibility, with plans for a so-called "Social VAT" to fund welfare and a tax on financial transactions.
The president is due to meet union leaders and employers for talks on Wednesday.
Sarkozy did not directly address the decision by Standard & Poor's to cut France's top-notch rating during the speech, despite criticism this weekend from opposition Socialist politicians who said it was his policies that had been downgraded, not France.
(Reporting by Yann Le Guernigou; Writing by James Regan; Editing by Matthew Jones)
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Monday, January 16, 2012
PFT: Packers not expected to put franchise tag on Flynn
Getty ImagesThough the script isn?t quite identical, what with the Giants launching their postseason run at home against a team they should have beaten, the 2007 Road Warriors storyline is in full bloom, thanks to a 37-20 trouncing of the Packers in Green Bay.
And it could have been worse, especially with referee Bill Leavy?s crew failing to give the Giants possession of a ball that clearly had been fumbled by Packers receiver Greg Jennings and later extending the home team?s final scoring drive by calling the Giants for a blow to the head of quarterback Aaron Rodgers ? when Rodgers actually fell into the chest of a defender.
The Giants outgained the Packers, 420 to 388, thanks in large part to 330 passing yards and three touchdowns from quarterback Eli Manning.? Green Bay, which had 13 turnovers all season, had four on Sunday, including two from Rodgers.
Peyton?s kid brother has climbed onto the upper echelon of quarterbacks with his play in the clutch, consistently converting third downs and generally making big plays.
For the Packers, the big plays were too few and far between.? And so the Giants, by winning the first playoff game in Wisconsin since the 2007 NFC title game, have a two-game postseason winning streak at Lambeau Field.
The Giants? win broke a 7-0 start to the postseason for the home teams.? It marks the second NFC upset of the weekend, with 36 and 37 points being the winning sum and neither the Saints nor the Packers ringing up those numbers.
Next up for the Giants, who lost to the Packers during the regular season by three, is a return to San Francisco, where the Giants fell by seven.? And if the Giants can turn the tables on the Niners, and if the Patriots can beat the Ravens, the rematch of Super Bowl XLII would also be a rematch of New York?s stirring November win, 24-20, at New England.
Of course, the Harbaugh brothers may have something to say about a Giants-Pats rematch.? Jim and John likely have dreams (or maybe nightmares) of a brother vs. brother return bout on the biggest stage in sports.
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Self-Healing iPhone Cases Could Save Your Clumsy Ass [Phones]
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